재발 위험 큰 VETC 간암, 유전자 발현 차이 확인
Gene Expression Differences Confirmed in VETC Liver Cancer, a Pattern With High Recurrence Risk
Part of the August 22, 2026 daily edition
서울대병원 연구팀이 간세포암 조직을 공간전사체 기법으로 분석해 VETC 간암의 분자적 특성을 살펴봤습니다. VETC는 종양세포 덩어리를 혈관이 둘러싸는 형태로, 이 패턴을 보이면 수술 후 재발 위험이 크고 생존율은 더 떨어집니다. 분석 결과 VETC 양성 영역은 음성 영역과 비교해 유전자 39개는 발현이 늘고 235개는 줄었습니다. LAMTOR2 단백질도 VETC 양성 간암에서 71%, 음성 간암에서 27%로 차이를 보였습니다. 연구 결과는 국제학술지 ‘헤파톨로지 인터내셔널’ 온라인판에 게재됐습니다.
Translation
A research team at Seoul National University Hospital analysed liver cancer tissue using spatial transcriptomics to look at the molecular characteristics of VETC liver cancer. VETC is a form in which blood vessels surround clusters of tumour cells, and when this pattern appears the risk of recurrence after surgery is high and the survival rate falls further. The analysis found that, compared with VETC-negative areas, positive areas had 39 genes with increased expression and 235 with decreased expression. The LAMTOR2 protein showed a difference too, appearing in 71 percent of VETC-positive liver cancers and 27 percent of negative ones. The findings were published in the online edition of the international journal Hepatology International.
Vocabulary
- 종양명사 (noun)tumour
- 혈관명사 (noun)blood vessel
- 재발명사 (noun)recurrence, relapse
- 생존율명사 (noun)survival rate
- 유전자명사 (noun)gene
- 발현명사 (noun)expression (of a gene)
- 단백질명사 (noun)protein
- 학술지명사 (noun)academic journal
Grammar points
N과/와 비교해compared with N
Sets up an explicit comparison. 과 follows a consonant, 와 a vowel, and the whole phrase usually sits just before the thing being measured. 비교해 is the -아/어 form of 비교하다 used adverbially; 비교하여 is the same thing in stiffer written style. The article measures one tissue type against another: 음성 영역과 비교해 유전자 39개는 늘고.
Example: 지난해와 비교해 학생 수가 줄었습니다.
Compared with last year, the number of students has fallen.
-(으)면if, when
The general conditional. Korean does not separate 'if' from 'when' the way English does — -(으)면 covers both, and context decides which reading fits. In scientific writing it usually states a regularity rather than a one-off possibility, as here: 이 패턴을 보이면 재발 위험이 크고 — whenever the pattern appears, the risk is high.
Example: 물은 백 도가 되면 끓습니다.
Water boils when it reaches one hundred degrees.
N을/를 보이다to show N, to exhibit N
Literally 'to show N', used of something displaying a property rather than a person showing an object. Research and statistics writing relies on it: 차이를 보였습니다 ('showed a difference'), 패턴을 보이면 ('if it shows the pattern'). The subject is the thing being described, not an agent doing the showing, so English often turns it around into 'a difference was seen'.
Example: 두 집단은 뚜렷한 차이를 보였습니다.
The two groups showed a clear difference.
More in this edition
Life
Expert
100세 이상 8604명…집에서 사는 이들 중 20.7%는 혼자
Korea Counts 8,604 People Aged 100 or Over; Among Those Living at Home, 20.7 Percent Live Alone
Society
Beginner
광교 산책로에 나타난 대형 도마뱀, 11일 만에 포획
Large Lizard That Appeared on a Gwanggyo Walking Path Is Caught After 11 Days
Policy
Advanced
국립대병원 소관, 교육부에서 복지부로…21년 만의 이관
National University Hospitals Pass From the Education Ministry to Health and Welfare, 21 Years On
Economy
Intermediate
서울 술집·치킨집 줄고 피부관리실·반찬가게 늘어
Bars and Fried-Chicken Shops Shrink in Seoul While Skincare Salons and Side-Dish Stores Grow